The relationship between stress and road safety has been studied for many years, but the effect of globalstress and its joint effect with personality on driving behavior have received little attention in previ-ous studies. This study aimed to elucidate the impact of global stress and various personality traits ondriving behavior. 242 drivers completed the Perceived Stress Scale-10 (PSS-10), the Dula Dangerous Driv-ing Index (DDDI), and several personality trait scales related to anger, sensation seeking, and altruism.The results showed that perceived stress and sensation seeking were significantly correlated with thefour subcategories of dangerous driving behavior, namely, negative cognitive/emotional driving (NCED),aggressive driving (AD), risky driving (RD), and drunk driving (DD). Moreover, anger was positively cor-related with negative cognitive/emotional driving, aggressive driving, and risky driving, and altruismwas negatively correlated with aggressive driving and drunk driving. Hierarchical multiple regressionswere applied to analyze the mediating effect of personality traits, and the results showed that angermediated the relationship between stress and dangerous driving behavior and that this mediating rolewas especially strong for negative cognitive/emotional driving and aggressive driving. Collectively, theresults showed that stress is an important factor that can affect people’s driving behavior but that per-sonality traits mediate the effect of stress on driving behavior. The findings from this study regarding therelationship among stress, anger, and dangerous driving behavior could be applied in the development ofintervention programs for stress and anger management in order to improve drivers’ ability to manageemotional thoughts and adjust their behavior on the road.