Neuropsychopathology of psychotic disorders and identification of endophenotypes/biomarkers for these clinical groups such as schizophrenia and bipolar disorders

Study of neuropsychological performances along the continuum of psychosis

Application of social cognitive neuroscience (social psychology, cognitive sciences, neuropsychology) to the development of clinical assessment and intervention for psychotic disorders and at-risk individuals

Measurement issues in clinical practice (e.g., development and validation of ecological valid test of neuropsychological performance, and articulating the laboratory-based test results to everyday life performance)

Developmental psychopathology

Asian Representative for International Neuropsychological Society; Committee member for Schizophrenia International Research Society; Steering committee member of International Consortium for Schizotypy Research; Founding member of the Schizotypy Working Group of EGNIMA; Physiopsychology sub-committee member of the Chinese Psychological Association.

Co-editor-in-chief for PsyCh Journal, editorial board for Biological Psychiatry: Global Open Science, Cognitive Neuropsychiatry, Journal of Psychopathology and Clinical Sciences (formerly named Journal of Abnormal Psychology), Neuropsychology, Neuropsychological Rehabilitation, Progress in Neuropsychopharmacology and Biological Psychiatry, Schizophrenia Research, Schizophrenia Research Cognition, and Advances in Psychological Sciences (Chinese).

A total of more than 600 peer-reviewed papers, joint editor for 1 book and 13 book chapters since 2000
Total publications = 600*; Total citations: 19,133 (excluding self-citation: 17,518) March 11 2023*, h-index: 56*
2019 Highly cited scholars (cross-field) (Web of Science Group)
2020 World's Top 2% Scientists 2020 Career-long impact and 2020 Single year impact by Scopus
2021 World's Top 2% Scientists 2020 Career-long impact and 2020 Single year impact by Scopus

1. Chan, R. C. K.*, Gottesman, I. I. (2008). Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star? Neuroscience and Biobehavioral Reviews, 32, 957-971.

2. Zhao, Q., Li, Z., Huang, J., Yan, C., …Chan, R. C. K.*. (2014). Neurological soft signs are not “soft” in brain structure and functional networks: Evidence from ALE meta-analysis. Schizophrenia Bulletin, 40(3): 626-641. doi: 10.1093/schbul/sbt063

3. Chan, R. C. K*., Xie, W., Geng, F. L., …. (2016). Clinical utility and lifespan profiling of neurological soft signs in schizophrenia spectrum disorders, Schizophrenia Bulletin, 42(3), 560-570.

4. Xie, D. J.#, Lui, S. S. Y.#, Geng, F. L., … Chan, R. C. K. * (2018). Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypyal individuals. Psychological Medicine, 48(9), 1474-1483. DOI 10.1017/S0033291717002926

5. Yang, Z. Y., Xie,D. J., Zou, Y. M., … Chan, R. C. K.* (2018). Prospection deficits in schizophrenia: Evidence from clinical and subclinical samples. Journal of Abnormal Psychology, 127(7), 710-721.

6. Li, Z., Wang, Y., Yan, C., Cheung, E. F. C., Docherty, A. R., Sham, P. C., Gur, R. E., Gur, R. C., Chan, R. C. K. * (2019). Inheritance of neural substrates for motivation and pleasure experience. Psychological Science, 30(8),1205-1217.

7. Wang, Y. M., Zou, L. Q., Xie, W. L., …, Chan, R. C. K. * (2019). Altered functional connectivity of the default mode network in patients with schizo-obsessive comorbidity: A comparison between schizophrenia and obsessive-compulsive disorder. Schizophrenia Bulletin, 4(1), 199-210.

8. Wang, Y. Y., Ge, M. H., Zhu, G. H., Jiang, N. Z., Wang, G. Z., Lv, S. X., Zhang, Q., Guo, J. N., Tian, X., Lui, S. S. Y., Cheung, E. F. C., Heerey, E. A., Sun, H. W.*, Chan, R. C. K. * (2020). Emotion-behaviour decoupling in individuals with schizophrenia, bipolar disorder and major depressive disorder. Journal of Abnormal Psychology, 129(4), 331–342.

9. Cai, X. L., Wang, Y. M., Wang, Y.,… Chan, R. C. K.* (2021). Neurological soft signs are associated with altered cerebellar-cerebral functional connectivity in schizophrenia. Schizophrenia Bulletin, 47(5), 1452-1462.https://doi.org/10.1093/schbul/sbaa200

10. Chan, R. C. K.*, Wang, L. L., Lui, S. S. Y. (2022). Theories and models of negative symptoms in schizophrenia and clinical implications. Nature Reviews Psychology, DOI: https://doi.org/10.1038/s44159-022-00065-9