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Guo Liyuan
Associate Professor
Tel:  010-64855841
Fax:  010-64855841
Mailing Address:  16 Lincui Road, Chaoyang District, Beijing 100101, China
Email:  guoly@psych.ac.cn
Website:  http://bioinfo.psych.ac.cn
Resume:

2004.9-2009.7 PhD in biochemistry and molecular biology, Peking University Health Science Center 
1999.9-2004.7 Bachelor in medicine, Shanxi Medical University 
Research Interests:

Research Experience

1. Regulatory feature analysis on human variants in whole genome scale.

2. Construction and analysis of gene-Regulatory network after chronic stress.

3. Multiple level knowledge base development for major depressive disorder (MDD).

4. Biological explanation for analysis result of ICSNPathway, which is a web sever for GWAS data mining.

5. Involvement of STAT5a signaling in morphine induced up-regulation of the cyclin D1.

6. Functional research on SIV Nef protein.

 

Research Interest

1. The development of analysis platform for mental disorder related genetic information.

2. Gene-environment interplay in mental disorder.

3. Gene regulatory network in mental disorder.
Community service:
Achievements:
Selected Publications:

1. Guo, L.Y*., Jin, B*., Zhang, Y.D. and Wang, J#. (2020) Identification of a missense ARSA mutation in metachromatic leukodystrophy and its potential pathogenic mechanism. Mol Genet Genom Med.
2. Guo, L.Y.*, Lin, W., Zhang, Y.D. and Wang, J#. (2020) A Systematic Analysis Revealed the Potential Gene Regulatory Processes of ATRA-Triggered Neuroblastoma Differentiation and Identified a Novel RA Response Sequence in the NTRK2 Gene. Biomed Res Int, 2020.
3. Wu, M.S*., Fang, K.C*., Wang, W.X., Lin, W., Guo, L.Y.# and Wang, J#. (2019) Identification of key genes and pathways for Alzheimer’s disease via combined analysis of genome-wide expression profiling in the hippocampus. Biophysics Reports.
4. Guo, L.Y.*, Lin, W., Zhang, Y.D., Li, W.H. and Wang, J#. (2019) BEST: a web server for brain expression Spatio-temporal pattern analysis. Bmc Bioinformatics, 20.
5. Guo, L.Y.*# and Wang, J.*# (2018) rSNPBase 3.0: an updated database of SNP-related regulatory elements, element-gene pairs and SNP-based gene regulatory networks. Nucleic Acids Res, 46, D1111-D1116.
6. Qu, S.S*., Du, Y., Chang, S.H., Guo, L.Y., Fang, K.C., Li, Y.Z., Zhang, F.C., Zhang, K.L. and Wang, J#. (2017) Common variants near IKZF1 are associated with primary Sjogren's syndrome in Han Chinese. Plos One, 12.
7. Wang, J.L*., Qu, S.S., Wang, W.X., Guo, L.Y., Zhang, K.L., Chang, S.H#. and Wang, J.# (2016) A combined analysis of genome-wide expression profiling of bipolar disorder in human prefrontal cortex. J Psychiatr Res, 82, 23-29.
8. Guo, L.Y.*, Du, Y.*, Qu, S.S. and Wang, J#. (2016) rVarBase: an updated database for regulatory features of human variants. Nucleic Acids Res, 44, D888-D893.
9. Zhang, K.L., Chang, S.H., Guo, L.Y. and Wang, J#. (2015) I-GSEA4GWAS v2: a web server for functional analysis of SNPs in trait-associated pathways identified from genome-wide association study. Protein Cell, 6, 221-224.
10. Guo, L.Y.*#, Du, Y. and Wang, J#. (2015) Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research. Sci Rep-Uk, 5.
11. Guo, L.Y.*, Du, Y., Chang, S.H., Zhang, W.N. and Wang, J#. (2014) Applying Differentially Expressed Genes From Rodent Models of Chronic Stress to Research of Stress-Related Disease: An Online Database. Psychosom Med, 76, 644-649.
12. Guo, L.Y.*, Du, Y.*, Chang, S.H., Zhang, K.L. and Wang, J.# (2014) rSNPBase: a database for curated regulatory SNPs. Nucleic Acids Res, 42, D1033-D1039.
13. Zhang, W.N.*, Chang, S.H., Guo, L.Y., Zhang, K.L. and Wang, J#. (2013) The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies. J Affect Disorders, 151, 531-539.
14. Guo, L.Y.*, Zhang, W.N.*, Chang, S.H.*, Zhang, L.Y., Ott, J. and Wang, J# (2012) MK4MDD: A Multi-Level Knowledge Base and Analysis Platform for Major Depressive Disorder. Plos One, 7.
15. Zhang, K.L., Chang, S.H., Cui, S.J., Guo, L.Y., Zhang, L.Y. and Wang, J.# (2011) ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework. Nucleic Acids Res, 39, W437-W443.
Grants:

1. National Natural Science Foundation of China (81201046): Construction and analysis of gene expression regulatory network in whole brain of BALB/c mice exposed to the chronic mild stress paradigm.
2. Institute of Psychology, CAS (Y0CX411S01): Multiple level biomarkers database for major depressive disorder (BD4D).
3. Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences: Chronic mild stress related gene regulation-network analysis in mice frontal cortex.