Location:Home>Scientist>Faculty and Staff
Wang Weiwen
professor
Tel:  86-10-64864516
Fax:  86-10-64872070
Mailing Address:  16 Lincui Road, Chaoyang District, Beijing 100101, China
Email:  wangww@psych.ac.cn
Website:  
Resume:

EDUCATION
Ph. D. Psychology – Institute of Psychology, Chinese Academy of Sciences   June 2004
M.S. Pharmacy – Shenyang University of Pharmacy   June 1997
B.S. Pharmacy – Xinjiang Medical University   June 1994

PROFESSIONAL EXPERIENCE
2016-     Professor, Institute of Psychology, Chinese Academy of Sciences
2005-2016 Associate Professor, Institute of Psychology, Chinese Academy of Sciences
2010     Visiting scholar, Pediatric Research Center, The Children's Hospital of Philadelphia 
1998-2004 Assistant Professor, Institute of Psychology, Chinese Academy of Sciences
Research Interests:
My research interests focus on psycho-neuro-immunological mechanisms of stress and related psychiatric disorders. In my lab, multiple techniques, including behavior, genetic and epigenetic, molecular biology and electrophysiology, are used to elucidate how environmental factors, especially early adverse experiences, cause emotional and cognitive dysfunction, and the relationships with the pathogenesis and treatment of psychiatric disorders, including depression, anxiety, and PTSD, etc. My group and collaborators have published over 70 papers in this broad field, most relating to animal research as well as part studies in humans. In recent years, our work has continually been funded by National Natural Science Foundation of China (NSFC), the National Key Technology Research and Development Program of China, the Chinese Academy of Sciences (CAS), the Institute of Psychology, and CAS Key Laboratory of Mental Health. 
Community service:

Since 2018 Vice director, Physiological Psychology Branch, Chinese Psychological Society

Since 2017 Vice director, Stress Neurobiology Branch, Chinese Neuroscience Society

Since 2013 Member of Council, Physiological Psychology Branch, Chinese Psychological Society

Since 2013 Member of Council, Psychosomatic Medicine Branch, Chinese Association for Mental Health

Since 2015 Member of Council, Physiology of Stress Branch, the Chinese Physiological Society

Since 2017 Member of Council, Neurobiology of Stress Branch, the Chinese Society for Neuroscience

Since 2015 Member of Council, Animal behavior Branch, the Chinese Zoological Society

 
Achievements:
 
Selected Publications:

（2015-）:

  • Xu, Haiyun; Wang, Weiwen; Ellenbroek, Bart; You, Zili. Editorial: Cognitive Dysfunctions in Psychiatric Disorders: Brain-Immune Interaction Mechanisms and Integrative Therapeutic Approaches. Frontiers in Integrative Neuroscience, 2021, 15: 0-649425. 
  • Ge, Li-Kun; Hu, Zhuoer; Wang, Weiwen; Siu, Parco M.; Wei, Gao-Xia. Aerobic Exercise Decreases Negative Affect by Modulating Orbitofrontal-Amygdala Connectivity in Adolescents. Life-Basel, 2021, 11(6): 0-577. 
  • Keliang Pang, Richeng Jiang, Wei Zhang, Zhengyi Yang, Lin-Lin Li, Makoto Shimozawa, Simone Tambaro, Johanna Mayer, Baogui Zhang, Man Li, Jiesi Wang, Hang Liu, Ailing Yang, Xi Chen, Jiazheng Liu, Bengt Winblad, Hua Han, Tianzi Jiang, Wang Weiwen, Per Nilsson, Wei Guo, & Lu Bai* (2021). An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments. Cell Research, 32, 157– 175. 
  • Xu H., Zhang XY, Wang WW, Wang JS. Hydroxychloroquine increased psychiatric-like behaviors and disrupted the expression of related genes in the mouse brain. Frontiers in Pharmacology. 2021, doi: 10.3389/fphar.2021.633112
  • Hang Xu, Jiesi Wang, Haiyang Jing, Bart Ellenbroek, Feng Shao, Weiwen Wang*. mPFC GABAergic  transmission mediated the role of BDNF signaling in cognitive impairment but not anxiety induced by adolescent social stress, Neuropharmacology, 2021, 184,108412.
  • HaoZhou, Jiesi Wang, Yu Zhang, Feng Shao* and Weiwen Wang*. The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation. FrontiersinIntegrativeNeuroscience. September 2020, Volume14: Article 551676.
  • Qiong Wang, Yingjuan Liu, Jianxu Zhang* and Weiwen Wang*. Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice. Frontiers in Psychology. January2020, 10: 3028.
  • Yuanyuan Xin, Zhuxi Yao, Weiwen Wang, Yuejia Luo, Andr_e Aleman and Jianhui Wu. Recent life stress predicts blunted acute stress response and the role of executive control. STRESS. 2020, VOL. 23, NO. 3, 359–367. doi.org/10.1080/10253890.2019.1687684
  • Yu Zhang, Hang Xu, Jiesi Wang, Fengyan Ren, Feng Shao, Bart Ellenbroek, Wenjuan Lin, Weiwen Wang？ (2019). Transient upregulation of immune activity induced by adolescent social stress is involved in cognitive de？cit in adult male mice and early intervention with minocycline. Behavioral Brain Research, 374, https://doi.org/10.1016/j.bbr.2019.112136.
  • Yu Zhang, Hang Xu, Fan Zhang, Feng Shao, Bart Ellenbroek, Jiesi Wang, Weiwen Wang*. (2019). Deficiencies of microglia and TNFa in the mPFC-mediated cognitive inflexibility induced by social stress during adolescence. Brain, behavior and immunity, on-line.
  • Wang, W. *, Wang, L., Xu, H., Cao, C., Liu, P., Luo, S., . . . Zhang, X. (2019). Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake. J Affect Disord, 248, 52-58. doi: 10.1016/j.jad.2019.01.029
  • Li, M., Xu, H., & Wang, W. * (2018). An Improved Model of Physical and Emotional Social Defeat: Different Effects on Social Behavior and Body Weight of Adolescent Mice by Interaction With Social Support. Frontiers in Psychiatry, 9(688). doi: 10.3389/fpsyt.2018.00688
  • Hang Xu, Jiesi Wang, Ke Zhang, Mei Zhao, Bart Ellenbroek, Feng Shao*, Weiwen Wang*. Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice. Psychoneuroendocrinology, 2018, 88: 92-101.
  • Zhang, Q., Chen, Z., Chen, S., Yu, T., Wang, J., Wang, W., & Deng, H. (2018). Correlations of hair level with salivary level in cortisol and cortisone. Life Sci, 193, 57-63. doi: 10.1016/j.lfs.2017.11.037
  • Qiong Wang, Feng Shao and Weiwen Wang*. Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress. Neural Plasticity, 2018, doi.org/10.1155/2018/9870985
  • Sun, Lan, Min, Li, Li, Man, Shao, Feng, & Wang, Weiwen* (2018). Transcriptomic analysis reveals oxidative phosphorylation activation in an adolescent social isolation rat model. BRAIN RESEARCH BULLETIN,142,304-312.
  • Man Li; Weiwen Wang#; Lan Sun; Wei Du; Hao Zhou; Feng Shao, Chronic clozapine treatment improves the alterations of prepulse inhibition and BDNF mRNA expression in the medial prefrontal cortex that are induced by adolescent social isolation. Behavioural Pharmacology. 2018, DOI 10.1097/FBP.0000000000000419.
  • Bart A. Ellenbroek, Weiwen Wang. The Translational Umbrella - A Novel Approach to the Study of the Biological Basis of Mental Health. OBM Neurobiology, 2018; 2(1), doi:10.21926/obm.neurobiol.1801008
  • Lan Sun, Li Min, Hao Zhou, Man Li, Feng Shao*, Weiwen Wang*, Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats. Behav Brain Res, 2017, 333: p. 258-266.
  • Zhang, Y., Shao, F., Wang, Q., Xie, X., Wang, W.W. * (2017). Neuroplastic correlates in the mPFC underlying the impairment of stress-coping ability and cognitive flexibility in adult rats exposed to chronic mild stress during adolescence. Neural Plasticity, 10. doi: 10.1155/2017/9382797
  • Jenny Berrío, Weiwen Wang, Bart A. Ellenbroek. Perspectives on the Neurobiology of Antipsychotic Drugs in Psychiatric Disorders. OBM Neurobiology.2017,1(1): doi:10.21926/obm.neurobiol.1701001
  • Xu, H., Zhang, Y., Zhang, F., Yuan, S., Shao, F., & Wang, W. * (2016). Effects of Duloxetine Treatment on Cognitive Flexibility and BDNF Expression in the mPFC of Adult Male Mice Exposed to Social Stress during Adolescence. Frontiers in Molecular Neuroscience, 9, 95.
  • Zhang, F., Yuan, S., Shao, F., & Wang, W.W. * (2016). Adolescent social defeat induced alterations in social behavior and cognitive flexibility in adult mice: effects of developmental stage and social condition. Frontiers in Behavioral Neuroscience, 10, 149,1-11.
  • Li, M., Du, W., Shao, F. *, Wang, W.W. * (2016). Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence. Behav Brain Res, 313, 177-183.
  • Mwanza, C., Chen, Z., Zhang, Q., Chen, S., Wang, W. W., & Deng, H.H. * (2016). Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. Journal of Chromatography B, 1028, 1-10.
  • Tian Yu, Hang Xu, Weiwen Wang, Shifei Li, Zheng Chen, Huihua Deng*. Determination of endogenous corticosterone in rodent’s blood, brainand hair with LC–APCI–MS/MS. Journal of Chromatography B, 2015, 1002: 267–276
  • Qiong Wang, Feng Shao*, Weiwen Wang*. Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats. Frontiers in Molecular Neuroscience. 2015，8：49：1-9
  • Weiwen Wang*, Huihua Deng, Li Wang*, Chengqi Cao,Hang Xu, Jianxin Zhang. Hair cortisone level is associated with PTSD’s dysphoric arousal symptoms in highly traumatized Chinese females. Journal of affective disorders, 2015, 182, 18-22
  • Yan Jin, Bin Luo, Yan-Yan Su,Xin-Xing Wang, Liang Chen*, Ming, Wang, Wei-Wen*, Lin Chen*. Sodium salicylate suppresses GABAergic 1 inhibitory activity in neurons of rodent dorsal raphe nucleus. Plos one, 2015, 10(5): e0126956.
  • Qiong Wang, Man Li, Wei Du, Feng Shao*, Weiwen Wang*. The different effects of maternal separation on spatial learning and reversal learning in rats. Behavioural Brain Research, 2015, 280: 16–23.
  • Li Wang, Chengqi Cao, Weiwen Wang*, Hang Xu, Jianxin Zhang, Huihua Deng, Xiangyang Zhang. Linking hair cortisol levels to phenotypic heterogeneity of posttraumatic stress symptomatology in highly traumatized Chinese females. Biological Psychiatry. 2015; 77 :e21–e22
Grants:

Projects from National Natural Science Foundation of China
“Central immune mechanisms underlying cognitive dysfunction in depression induced by adolescent stress and new intervention strategy”(31771217), 2018.01-2021.12, Director
“The developmental effect of early adolescent social stress on depressive behavior and prefrontal GABAergic system and its relationship”(81471122), 2015.01-2018.12, Director
“BDNF mechanisms underlying the changes of emotion and cognition induced by adolescent stress and early intervention”(91132728), 2012.01-2014.12, Director
“The neurobiological mechanisms underlying reversal learning dysfunction of schizophrenia induced by early isolated stress”(30370482), 2007.01 ?2009.12, collaborator
“Role of Heat Shock Protein70 in Stress-induced Immune Modulation”(30500158), 2006.01 ?2008.12, Director

Projects from National Basic Research Program of China (973) Program
“Genetic and environmental interactions in mechanisms of depression and schizophrenia”(2007CB512306), 2007.01 – 2011.12, main research member in subproject

Projects from the Chinese Academy of Sciences
“Psychoneural basis of the clinical heterogeneity of PTSD” , 2013.01 – 2016.12，main research member
“Schizophrenia-like and Depression-like behavior of rats in Puberty and its neural basis” (KSCX2-YW-R-131), 2008.01 – 2011.12, Subproject director
“Early recognition of psychiatric disorders” (（KSCX2-EW-J-8）)，2011.01 – 2013.12，main research member
“Psychoneural basis of the clinical heterogeneity of PTSD”, 2013.01-2016.12, main research member

Projects from Institute of Psychology, CAS
“Reward circuits changes associated with child trauma and vulnerability to anhedonia depression” 2016.01 ?2018.12, Co-Director
“Temporal characteristics of changes in activity of HPA axis among PTSD patients”2014.01 ?2016.12, Co-Director
“The effects of adolescent stress on depressive behaviour and neural plasticity”(O9CX133013), 2009.01 ?2010.12, Director
“BDNF epigenetic mechanisms underlying depressive behaviors induced by adolescent stress”,2012.01-2013.12, Director