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Zheng Xigeng |
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Tel: 86-10-64877528 |
Fax: 86-10-64872070 |
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Mailing Address: Dr. Zheng Xigeng, Key Lab of Mental Health, Institute of Psychology, The Chinese Academy of Sciences, Beishatan, Chaoyang District, Beijing 100101, P.R.China |
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Email: zhengxg@psych.ac.cn |
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Website: |
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Resume: |
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I work in Laboratory of Mental Health of the Institute of Psychology of the Chinese Academy of Scienes (CAS) since 2003. My main research interests include the neurobiobehavioral mechanisms of stress-related psychiatric disorders. Several topics have been concentrated from behavioral, psychological and neural level, e.g. 1) relationship between activities of mineralocorticoids and glucocorticoids and long-existed conditioned fear, its extinction and relapse; 2) Role of Mesolimbic Dopaminergic System in Stress-induced Depressive Behaviors; 3) The neurobehavioral distinctions between morphine use morphine addiction. More than 40 peer-reviewed research papers have been published in these fields which were mainly indexed in SCI, SSCI and CSCD database.
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Research Interests: |
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Neurobeahvioral mechanisms in stress pathophysiology and related psychiatric disorders.
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Achievements: |
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Award for Young Scientists, Beijing Science and Technology Association.
Dec. 2005
Award of Research Excellency for Young Scientists, Beijing Neuroscience Society.
Jan. 2005
Award of Excellent Doctoral Dissertation of the Chinese Academy of Sciences, to X. G. Zheng
2003-2004
IPCAS Predential Award to X. G. Zheng (1st grade, IPCAS: Institute of Psychology, The Chinese Academy of Sciences)
Jul. 2003
Special Innovation Grant to Graduate Students of the Chinese Academy of Sciences, P. R. China, to X. G. Zheng
Sept. 2002-Jul. 2003
Research assistantship for Ph.D. candidacy, Institute of Psychology, The Chinese Academy of Sciences
Dec. 2000-Jul. 2003
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Selected Publications: |
1. Xigeng Zheng,？, Olivier Deschaux, Jennifer Lavigne, Ophélie Nachon, Carine Cleren, Jean-Luc Moreau, René Garcia, Prefrontal tetanic stimulation prevents sub-conditioning procedure-provoked, but not acute stress-provoked, reemergence of extinguished fear, Neurobiology of Learning & Memory, 2013; 101:33-38 (？: co-first author)
2. Olivier Deschaux？, Xigeng Zheng？, Jennifer Lavigne, Ophélie Nachon, Carine Cleren, Jean-Luc Moreau, René Garcia, Post-extinction fluoxetine treatment prevents both sub-conditioning procedure-provoked and acute stress-provoked reemergence of extinguished fear, Pychopharmacology, 2013; 225(1): 209-216 (？: co-first author)
3. Xian-Li An, Xi-Geng Zheng*, Jing Liang, and Yun-Jing Bai, Corticosterone combined with intramedial prefrontal cortex infusion of SCH 23390 impairs the strong fear response in high-fear-reactivity rats, Psych Journal, 2012 (Accepted)
4. Bai Yunjing, Peng Yonghua, Liang Jing, Zheng Xigeng*, Differential patterns of Neuronal Activation in Rostral versus Caudal Ventral Tegmental Area Involved in Behavioral Sensitization Induced by an Escalating Dose Morphine Administration Paradigm, European Journal of Pharmarcology, 2012; 689:118-124
5. Ding, X., Liang, J., Zheng, X., Bai, Y. Liu, Z., Li, Y., Xing, X., Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine, European Journal of Pharmacology, 2013 (accepted)
6. Jing Liang, Xigeng Zheng*; Jihuan Chen, Yingying Li, Xiaoli Xing, Yunjing Bai, Yingcong Li, Roles of BDNF, dopamine D3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization, European Neuropsychopharmacology, 2011; 21:825-834
7. Jing Liang, Ji-Huan Chen, Xiao-Hong Chen, Yong-Hua Peng, Xi-Geng Zheng*, Gene expression of conditioned locomotion and context-specific locomotor sensitization controlled by morphine-associated environment, Behavioural Brain Research 2011; 216:321-331
8. Youhong Li, Xigeng Zheng*, Jing Liang, Yonghua Peng, Coexistence of Anhedonia and Anxiety-independent Increased Novelty-seeking Behavior in the Chronic Mild Stress Model of Depression, Behavioural Processes, 2010; 83:331-339
9. LIANG Jing, PENG YongHua, GE XiaoXiang, ZHENG XiGeng*. The expression of morphine-induced behavioral sensitization depends more on treatment regimen and environmental novelty than on conditioned drug effects. Chinese Science Bulletin, 2010; 55(3):1-5
10. Bai, Y. J., Li, Y. H., Zheng, X. G., Han, J., Yang, X. Y., Sui, N. Orexin A attenuates unconditioned sexual motivation in male rats, Pharmacology Biochemistry Behavior, 2009; 91:581-589
11. Li Yonghui, Zheng Xigeng, Bai Yunjing, Yang Xiaoyan, Sui Nan, Opposite Effects of MK-801 on The Expression of Food and Morphine -induced Conditioned Place Preference in Rats, Journal of Psychopharmacology, 2006; 20(1):40-46
12. Ya Yang？, Xigeng Zheng？, Yongfu Wang, Jun Cao, Zhifang Dong, Jingxia Cai, Nan Sui, Lin Xu. Stress Enables Synaptic Depression in CA1 Synapses by Acute and Chronic Morphine: Possible Mechanisms for Corticosterone on Opiate Addiction, The Journal of Neuroscience, 2004; 24(10):2412-20. (？: co-1st author)
13. Zheng Xigeng, Li Yonghui, Luo Xiaojing, Xiao Lin, Wang Dongmei, Liu Jie, Yang Xiaoyan, Sui Nan. Social crowding sensitizes high-responding rats to psychomotor stimulant effects of morphine Pharmacology Biochemistry and Behavior 2004; 79:213-8
14. X. G. Zheng, B. P. Tan, X. J. Luo, W. Xu, X. Y. Yang, N. Sui. Novelty-seeking behavior and stress-induced locomotion in rats of juvenile period differentially related to morphine place conditioning in their adulthood Behavioural Processes 2004; 65(1):15-23
15. Zheng Xigeng, Ke Xue, Tan Beiping, Luo Xiaojing, Xu Wei, Yang Xiaoyan, Sui Nan. Susceptibility to Morphine Place Conditioning: relationship with stress-induced locomotion and novelty-seeking behavior in juvenile and adult rats Pharmacology Biochemistry and Behavior 2003; 75:929-35
16. ZHENG Xi-Geng, LI Xin-Wang, YANG Xiao-Yan, SUI Nan. Effects of scopolamine and physostigmine on acquisition of morphine-treated rats in Morris water maze performance. Acta Pharmacologia Sinica 2002 (23) 5:476-80
17. Tan Beiping, Zheng Xigeng, Sui Nan. Effects of repeated morphine exposure on open-field activity and novelty seeking behavior in a playground maze Acta Psychologia Sinica, 2003；35: 93-98
18. Wang DM, Li J, Li YH , Zheng XG, Yang XY, SUI N, Post-training infusions of dopamine receptor antagonist into the basolateral amygdala prevent morphine-induce conditioned place preference, Acta Pharmacologia Sinica, 2006; 27:420-420 |
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Grants: |
1. National Natural Science Foundation Grant to X. G. Zheng, Title: The relationship between glucocorticoid activity during peri-trauma period and the long-existed conditioned fear and its extinction: Role of noradrenergic system in hippocampus and Amygdala (No. 30971057), Jan. 2010-Dec. 2012
2. National Natural Science Foundation Grant to X. G. Zheng, Title: Role of Mesolimbic Dopaminergic System in Stress-induced Depressive Behaviors (No. 30770722), Jan. 2008-Dec, 2010
3. National Natural Science Foundation Grant to X. G. Zheng, Title: Susceptibility to morphine: behavioral characteristics and gene expressions in the rat brain (No. 30470578), Jan. 2005-Dec. 2007
4. IPCAS Promotive Fund for Excellent Doctoral Dissertation Award of CAS (The Chinese Academy of Sciences); Title: Glucocorticoids around Peritrauma Period and Long-existed Conditioned Fear and Its Extinction: Role of Hippocampus and Amygdala, 2009.8-2011.8
5. IPCAS Science Development Fund (O8CX093009); Title: Role of Mesolimbic Dopaminergic System in Conditioned Fear and Its Extinction, 2008.5-2010.5
6. Academia Sinica Promotive Fund for Excellent Doctoral Dissertation Award of CAS (The Chinese Academy of Sciences) (O7CX191019), 2008.1-2010.12
7. IPCAS Presidential Research Grant to X. G. Zheng (No. 049, IPCAS: Institute of Psychology, The Chinese Academy of Sciences), Sept. 2003-Jul. 2005 |
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