The present study examined electroencephalogram profiles on a novel stimulus-response compatibility (SRC) task in order to elucidate the distinct brain mechanisms of stimulus-stimulus (S-S) and stimulus-response (S-R) conflict processing. The results showed that the SRC effects on reaction times (RTs) and N2 amplitudes were additive when both S-S and S-R conflicts existed. We also observed that, for both RTs and N2 amplitudes, the conflict adaptation effects-the reduced SRC effect following an incongruent trial versus a congruent trial-were present only when two consecutive trials involved the same type of conflict. Time-frequency analysis revealed that both S-S and S-R conflicts modulated power in the theta band, whereas S-S conflict additionally modulated power in the alpha and beta bands. In summary, our findings provide insight into the domain-specific conflict processing and the modular organization of cognitive control.