Home | Sitemap | Contact | 中文 | CAS
About Us
International Cooperation
Education & Training
Join Us
Societies & Publications
Location:Home>Research>Research Progress
Research Findings Support the Association of Neurological Soft Signs and Cerebellar-cerebral Functional Connectivity in Schizophrenia
Author: Dr.Raymond Chan      Update time: 2021/01/26
Text Size: A A A

Neurological soft signs (NSS) have been shown to be the important biomarkers for schizophrenia. These signs (including motor coordination, sensory integration and disinhibition) were conventionally thought to be minor neurological anomalies without any specific brain regions corresponding for the observed behavioural manifestations. Accumulating imaging findings have suggested these signs are actually associating with specific brain functional network. However, most of these studies have specifically focused on the association of motor coordination signs in patients with schizophrenia and general brain functional connectivity within the cerebral cortex. More recently, evidence suggests that the cerebellum plays an important node in multiple function networks accounting for various cognitive and perceptual impairments observed in patients with schizophrenia. However, little is known about the underlying cerebellar-cerebral functional connectivity associating with sensory integration signs in patients with schizophrenia.

Dr.Raymond Chan and his team from the Neuropsychology and Applied Cognitive Neuroscience (NACN) Laboratory and CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences have shown that cerebellar hypoactivation was associated with sensory integration in patients with schizophrenia and their unaffected siblings. Importantly, the cerebellar activation underlying sensory integration is heritable. Based on these findings, Dr. Chan and his team have recently conducted another study to further examine the specific relationship of NSS and cerebellar-cerebral resting-state functional connectivity (rsFC) in 51 patients with schizophrenia and 50 healthy controls. Their findings showed that positive correlations between NSS and rsFC of the cerebellum with the inferior frontal gyrus and the precuneus, and negative correlations between NSS and rsFC of the cerebellum with the inferior temporal gyrus in patients with schizophrenia. Moreover, they also found that cerebellar-prefrontal rsFC was also positively correlated with negative symptoms in schizophrenia patients. More importantly, similar findings were replicated in another sample of 34 patients with schizophrenia and 34 healthy controls.

Taken together, these findings demonstrate the important role of cerebellum and its connection to cerebral cortex contributing to both the NSS manifestations and negative symptoms in patients with schizophrenia. Such altered cerebellar-cerebral functional connectivity may share the same neural mechanism for NSS and negative symptoms in this clinical group. Besides, the cerebellar activation underlying sensory integration is heritable that suggested its role as a candidate endophenotype of schizophrenia.

This study was supported by a grant from the National Key Research and Development Programme, Beijing Municipal Science & Technology Commission Grant, the CAS Key Laboratory of Mental Health, Institute of Psychology, and the Philip KH Wong Foundation.

This paper is now published online in Schizophrenia Bulletin on 22 January 2021:

Cai, X. L., Wang, Y. M., Wang, Y., Zhou, H. Y., Huang, J., Wang, Y., Lui, S. S. Y., M?ller, A., Hung, K. S. Y., Mak, H. K. F., Sham, P. C., Cheung, E. F. C., Chan, R. C. K.* (in press). Neurological soft signs are associated with altered cerebellar-cerebral functional connectivity in schizophrenia. Schizophrenia Bulletin.

Related papers

- Li, Z., Huang, J., Hung, K. S. Y., Deng, Y., Wang, Y., Wang, Y., Lui, S. S. Y., Mak, Henry, K F., Sham, P. C., Cheung, E. F. C., ?ngür, D., Dazzan, P., Chan, R. C. K.* (2020). Cerebellar hypoactivation is associated with impaired sensory integration in schizophrenia. Journal of Abnormal Psychology, doi.org/10.1037/abn0000636 (https://psycnet.apa.org/record/2020-78357-001)

- Chan, R. C. K*., Xie, W., Geng, F. L., Wang, Y., Lui, S. S. Y., Wang, C. Y., Yu, X., Cheung, E. F. C., Rosenthal, R. (2016). Clinical utility and lifespan profiling of neurological soft signs in schizophrenia spectrum disorders, Schizophrenia Bulletin, 42(3), 560-570. doi:10.1093/schbul/sbv196

- Chan, R. C. K.*, Dai, S., Lui, S. S. Y., Ho, K K. Y., Hung, K. S. Y., Wang, Y., Geng, F. L., Li., Z., Cheung, E. F. C. (2015). Re-visiting the nature and relationships between neurological signs and neurocognitive functions in first-episode schizophrenia: An invariance model across time. Scientific Reports, 5: 11859.

- Chan, R. C. K.*, Huang, J, Zhao, Q, Wang, Y, Lai, YY, Hong, N., Shum, D.H.K., Cheung, EFC, Yu, X, Dazzan P. (2015).Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives. NeuroImage: Clinical. 9, 411–417

- Zhao, Q., Li, Z., Huang, J., Yan, C., Dazzan, P., Pantelis, C., Cheung, E. F. C., Lui, S. S. Y., Chan, R. C. K.*. (2014). Neurological soft signs are not “soft” in brain structure and functional networks: Evidence from ALE meta-analysis. Schizophrenia Bulletin, 40(3): 626-641.

- Chan, R. C. K.*, Xu, T., Heinrichs, R. W., Yu, Y., Wang, Y. (2010). Neurological soft signs in schizophrenia: A meta analysis. Schizophrenia Bulletin, 36(6), 1089-1104.

- Chan, R. C. K*., Xu, T., Heinrichs, R. W., Yu, Y., & Gong, Q. (2010). Neurological soft signs in non-psychotic first-degree relatives of patients with schizophrenia: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews,34, 889-896.

- Chan, R. C. K.*, Gottesman, I. I. (2008). Neurological soft signs as candidate endophenotypes for schizophrenia: A shooting star or a Northern star? Neuroscience and Biobehavioral Reviews, 32, 957-971.

Ms. LIU Chen
Institute of Psychology
Email: liuc@psych.ac.cn


16 Lincui Road, Chaoyang District, Beijing 100101, China. All Rights Reserved