Social anhedonia is a reduced ability to experience pleasure from social interaction. It is one of the core features for negative symptoms in schizophrenia. Recent findings suggest that people with high level of social anhedonia have already exhibited alteration in social brain network and diminished correlation with real-world social network size characteristics. However, most of these findings were done at the regions of interest approach that may not be able to capture the complex relationship between brain functional connectivity and real-life social behavioural adequately.

Dr. Raymond Chan’s team from the Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health of the Institute of Psychology has recently conducted a study to investigate the hub regions of resting-state social brain network (SBN) of 35 participants with high level of social anhedonia and 50 participants with low level of social anhedonia. They found that the right amygdala, left temporal lobe and right media superior frontal gyrus were the hub regions of SBN both in participants with high and low level of social anhedonia. Interestingly, they found that the left temporal lobe connected functional connectivity (FC) did not predict social network characteristics, while the other FCs strengthened the association with social network characteristics in participants with high level of social anhedonia. These findings were replicated in an independent sample of 33 participants with high level of social anhedonia and 32 participants with low level of social anhedonia suggesting the robustness and stability of the dissociation between hub-connected functional connectivity of the social brain network and real-world social network in people with social anhedonia. These findings may have an important implication to guide the development of non-pharmacological interventions for social function deficits in people with social anhedonia.

This study was supported by the Jiangsu Provincial Key Research and Development Programme and the Phillip K.H. Wong Foundation.

This study is now available online since August 18, 2022 from Psychiatry Research Neuroimaging
-        Zhang, J. Y., Hu, H. X., Wang, L. L., Wang, X., Wang, Y., Huang, J., Wang, Y., Lui, S. S. Y., Hui, L., Chan, R. C. K.* (in press). Decoupling between hub-connected functional connectivity of the social brain network and real-world social network in individuals with social anhedonia. Psychiatry Research Neuroimaging.

Related Publication
-        Zhang, Y. J.#, Li, Y.#, Wang, Y. M., Wang, S. K., Pu, C. C., Zhou, S. Z., Ma, Y. T., Wang, Y., Lui, S. S. Y., Yu, X., Chan, R. C. K.* (2021). Hub-connected functional connectivity within social brain network weakens the association with real-life social network in schizophrenia patients. European Archives of Psychiatry and Clinical Neuroscience.
-        Zhang, Y. J., Cai, X. L., Hu, H. X., Zhang, R. T., Wang, Y., Lui, S. S. Y., Cheung, E. F. C., Chan, R. C. K.* (2021). Social brain network predicts real-world social network in individuals with social anhedonia. Psychiatry Research Neuroimaging, 317, 111390.
-        Zhang, Y. J.#, Pu, C. C.#, Wang, Y. M., Zhang, R. T., Cai, X. L., Zhou, S. Z., Ma, Y. T., Wang, Y., Cheung, E. F. C., Lui, S. S. Y., Yu, X.*, Chan R. C. K.* (2021). Social brain network correlates with real-life social network in individuals with schizophrenia and social anhedonia. Schizophrenia Research, 232, 77-84.

LIU Chen
Institute of Psychology
Chinese Academy of Sciences
Beijing 100101, China.
E-mail: liuc@psych.ac.cn